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Detailed medicine guidance

Who can and cannot take olanzapine

NHS medicines information on who can take olanzapine and who may not be able to take it.

About this information

This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.

Who can take olanzapine

Most adults aged 18 years old and over can take olanzapine.

Who may not be able to take olanzapine

Olanzapine is not suitable for some people. To make sure it's safe for you, tell your doctor before starting to take it if you have:

  • ever had an allergic reaction to olanzapine or any other medicine
  • a heart problem, including an irregular heartbeat (arrhythmia)
  • low blood pressure
  • had a stroke or are at high risk of having a stroke
  • had a blood clot or someone in your family has had blood clots
  • ever had problems controlling the movements of your tongue, mouth and face
  • ever had a rare condition called neuroleptic malignant syndrome (symptoms include a high temperature, muscle stiffness, sweating, anxiety and excess saliva)
  • Parkinson's disease
  • dementia
  • ever had low levels of white blood cells
  • diabetes
  • epilepsy
  • liver or kidney problems
  • an abnormally high level of the hormone prolactin in your blood or if you have a possible prolactin-dependent tumour
  • glaucoma (high pressure in the eye)
  • severe constipation or you think you have a blockage in your bowels

View the original NHS website page ↗. Refreshed 19 August 2026.

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