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Side effects of olanzapine

NHS medicines information on side effects of olanzapine and what you can do to cope.

About this information

This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.

Common side effects of olanzapine

These common side effects of olanzapine may affect up to 1 in 10 people. There are things you can do to help cope with them:

Feeling sleepy in the day

Do not drive, cycle or use tools or machinery if you're feeling this way. Do not drink alcohol as this will make you feel more tired.

As your body gets used to olanzapine, these side effects should wear off. Speak to your doctor if they get worse or do not go away.

Putting on weight or an increase in your appetite

Try to eat a healthy, balanced diet without increasing your portion sizes. Do not snack on foods that contain a lot of calories, such as crisps, cakes, biscuits and sweets. If you feel hungry between meals, eat fruit and vegetables and low-calorie foods.

Regular exercise will also help to keep your weight stable.

Feeling dizzy

If olanzapine makes you feel dizzy when you stand up, get up slowly and hold on to something to steady your balance until your dizziness has passed. It should only last a few moments.

As your body gets used to your medicine this problem should get better.

Rash

It may help to take an antihistamine, which you can buy from a pharmacy. Ask your pharmacist which type is suitable for you to take while you're on olanzapine.

Constipation

Eat more high-fibre foods such as fresh fruit, vegetables and cereals. Try to drink several glasses of water or another non-alcoholic liquid every day. Try to exercise more regularly, for example, by going for a daily walk or run.

Speak to a doctor or pharmacist if the advice on how to cope does not help and a side effect is still bothering you or does not go away.

See your doctor if you have sexual problems such as lower libido in men or women, or problems getting an erection. These can be signs of hormone changes.

View the original NHS website page ↗. Refreshed 19 August 2026.

Licensed under the Open Government Licence v3.0 ↗. MyPHU is independent and is not endorsed by the NHS.

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