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Detailed medicine guidance

Who can and cannot take esomeprazole

NHS medicines information on who can take esomeprazole and who may not be able to take it.

About this information

This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.

Who can take esomeprazole

Most adults can take esomeprazole. Children should only have esomeprazole if a doctor prescribes it.

Who may not be able to take esomeprazole

Esomeprazole is not suitable for some people. To make sure it's safe for you, tell your doctor if you:

  • have ever had an allergic reaction to esomeprazole or any other medicine
  • have liver problems
  • are due to have an endoscopy - problems usually found during this procedure may not show up if you've used esomeprazole

If you're using esomeprazole that you have bought from a shop or pharmacy without a prescription, then you should speak to your doctor before taking it if you:

  • are losing weight without trying
  • keep being sick (vomiting), or are vomiting blood (this might look like dark coffee grounds)
  • feel weak or your skin looks paler than usual (this may not be as noticeable on brown or black skin)
  • have blood in your poo (your poo may look black or like tar)
  • have chest or stomach pain
  • have diarrhoea that is severe or does not get better
  • have problems with swallowing

View the original NHS website page ↗. Refreshed 19 August 2026.

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