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Detailed medicine guidance

Taking empagliflozin with other medicines and herbal supplements

NHS medicines information on possible interactions with empagliflozin and other medicines, herbal remedies and supplements.

About this information

This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.

Cautions with other medicines

There are some medicines that may increase the effects of empagliflozin. This can make you more likely to get side effects.

Tell your doctor if you're taking any of these medicines:

  • medicines that make you pee more (diuretics), such as furosemide – these can increase your risk of dehydration and lower your blood pressure
  • high blood pressure medicines, such as ramipril or amlodipine
  • other medicines that can lower your blood pressure – including some antidepressants, nitrates (for chest pain), baclofen (a muscle relaxant), tamsulosin (for an enlarged prostate), or co-careldopa or levodopa (for Parkinson's disease)
  • medicines that cause low blood sugar, such as insulin or gliclazide – your doctor may lower your dose of these other medicines to prevent hypos
Taking empagliflozin with painkillers

It's safe to take empagliflozin with everyday painkillers such as paracetamol and ibuprofen.

Mixing empagliflozin with herbal remedies and supplements

There is very little information about taking empagliflozin with herbal remedies and supplements. However, some herbal products such as karela, turmeric and ginseng can potentially cause low blood sugar (hypoglycaemia).

There's not enough information to say that other complementary medicines, supplements and herbal remedies are safe to take with empagliflozin. They're not tested in the same way as pharmacy and prescription medicines. They're generally not tested for the effect they have on other medicines.

Meds New IA (H2) - Cautions with other medicines alert

Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.

View the original NHS website page ↗. Refreshed 19 August 2026.

Licensed under the Open Government Licence v3.0 ↗. MyPHU is independent and is not endorsed by the NHS.

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