Taking amitriptyline for depression with other medicines and herbal supplements

Many medicines and amitriptyline can affect each other and increase the chances of side effects.

Always check with your doctor or a pharmacist before starting any new medicine while you're taking amitriptyline.

Taking amitriptyline with opioid medicines can increase your risk of becoming very drowsy and having breathing problems. Opioid medicines include codeine, morphine and oxycodone.

Tell your doctor if you've ever taken any other medicines for depression. Some antidepressants can affect the way amitriptyline works and can cause very high blood pressure. This can happen even after you stop taking them.