This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.
Dosage and how to take amitriptyline for depression
Amitriptyline tablets come in different strengths of 10mg, 25mg or 50mg.
Amitriptyline liquid also comes in 3 different strengths containing 10mg, 25mg or 50mg in a 5ml spoonful.
The usual dose of amitriptyline for depression in adults is 50mg a day (25mg twice a day).
Some people may need to start on a lower dose of 10mg to 25mg a day, to reduce the chance of side effects. This includes people with heart problems, and older people.
The dose will then be gradually increased, if necessary, until you and your doctor agree that you have found a dose that suits you.
The maximum recommended dose of amitriptyline is 150mg a day, but this should only be under the supervision of a specialist.
How to take it
You'll usually take amitriptyline twice a day.
Amitriptyline does not usually upset your stomach. You can take it with or without food.
Swallow the tablets whole with a drink of water. If you chew them, they taste bitter.
The liquid comes with a plastic syringe or spoon to help you measure out the right dose. If you do not have a syringe or spoon, ask your pharmacist for one. Do not use a kitchen teaspoon as it will not measure the right amount.
View the original NHS website page ↗. Refreshed 19 August 2026.
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