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Detailed medicine guidance

Taking varenicline with other medicines and herbal supplements

NHS medicines information on possible interactions with varenicline and other medicines, herbal remedies and supplements.

About this information

This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.

Cautions with other medicines

Varenicline does not usually have an effect on any other medicines. Check with your doctor before using varenicline with other stop smoking treatments.

However, when you stop smoking, with or without varenicline, your doctor may need to change your dose of medicines such as:

  • theophylline or aminophylline, medicines for breathing problems
  • erlotinib, a medicine to treat cancer
  • riociguat, a medicine to treat high blood pressure in the lungs (pulmonary arterial hypertension)
  • warfarin, a medicine to reduce blood clotting
  • insulin, to treat diabetes
  • olanzapine and clozapine, used to treat psychosis

View the original NHS website page ↗. Refreshed 19 August 2026.

Licensed under the Open Government Licence v3.0 ↗. MyPHU is independent and is not endorsed by the NHS.

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