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Detailed medicine guidance

Taking valproic acid with other medicines and herbal supplements

NHS medicines information on possible interactions with valproic acid and other medicines, herbal remedies and supplements.

About this information

This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.

Cautions with other medicines

There are some medicines that may affect how valproic acid works. Valproic acid can also affect the way other medicines work.

Tell your doctor if you're taking:

  • any other medicines for epilepsy such as carbamazepine
  • medicines for preventing blood clots such as warfarin
  • aspirin
  • cimetidine, a medicine for stomach ulcers
  • medicines to treat HIV and AIDS such as ritonavir
  • antibiotics such as erythromycin
  • medicines for depression or other mental health problems, such as venlafaxine, quetiapine or diazepam
  • cholesterol-lowering medicines such as cholestyramine
  • medicines to prevent malaria such as mefloquine or chloroquine

View the original NHS website page ↗. Refreshed 19 August 2026.

Licensed under the Open Government Licence v3.0 ↗. MyPHU is independent and is not endorsed by the NHS.

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