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Detailed medicine guidance

Taking risperidone with other medicines and herbal supplements

NHS medicines information on possible interactions with risperidone and other medicines, herbal remedies and supplements.

About this information

This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.

Cautions with other medicines

Some medicines may affect the way risperidone works and increase the chances of you having side effects.

Check with a pharmacist or doctor if you're taking any other medicines, including:

  • rifampicin (an antibiotic for treating tuberculosis (TB))
  • carbamazepine or phenytoin (medicines for epilepsy)
  • itraconazole (a medicine for treating fungal infections)
  • medicines that make you feel sleepy such as diazepam (benzodiazepines), morphine or tramadol (opioid painkillers) or chlorphenamine (an antihistamine) – risperidone can increase these sedating effects and make you feel more sleepy
  • medicines that cause a slow heartbeat
  • medicines to treat high blood pressure
  • medicines for Parkinson's disease such as levodopa
  • medicines that stimulate the brain such as methylphenidate
  • medicines that remove extra fluid from your body (diuretics) such as furosemide or chlorothiazide

These are not all the medicines that may cause problems if you take them with risperidone. For a full list, see the leaflet inside your medicine packet.

View the original NHS website page ↗. Refreshed 19 August 2026.

Licensed under the Open Government Licence v3.0 ↗. MyPHU is independent and is not endorsed by the NHS.

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