This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.
Cautions with other medicines
Oxybutynin may affect the way other medicines work, and other medicines may affect how oxybutynin works.
Tell your pharmacist or doctor if you're taking:
- amantadine, a medicine used for Parkinson's disease or for infections
- levodopa, used to treat Parkinson's disease
- phenothiazines, clozapine, haloperidol or benperidol, medicines for mental health problems
- donepezil, rivastigmine, galantamine or tacrine, medicines used for dementia
- amitriptyline, imipramine or dosulepin (tricyclic antidepressants), medicines for depression
- medicines used to make you feel sleepy (sedatives)
- anti-sickness medicines like prochlorperazine
- medicines for stomach and bowel problems like domperidone or metoclopramide
- digoxin, quinidine or disopyramide, medicines used to treat heart problems
- dipyridamole, used to treat blood problems
- chlorphenamine or diphenhydramine, medicines used to treat allergies
- any medicines used to treat irritable bowel syndrome, asthma, incontinence, motion sickness or movement disorders related to Parkinson's disease, that work in a similar way to oxybutynin
- erythromycin or other macrolide antibiotics used to treat bacterial infections
Taking oxybutynin with painkillers
It's safe to take oxybutynin with everyday painkillers like paracetamol.
View the original NHS website page ↗. Refreshed 19 August 2026.
Licensed under the Open Government Licence v3.0 ↗. MyPHU is independent and is not endorsed by the NHS.