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Detailed medicine guidance

Side effects of methylphenidate for adults

NHS medicines information on side effects of methylphenidate for adults and what you can do to cope.

About this information

This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.

Common side effects of methylphenidate

These common side effects of methylphenidate may happen in more than 1 in 100 people. Side effects will depend on the type and brand of methylphenidate you're taking.

There are things you can do to help cope with them:

Headaches

Make sure you rest and drink plenty of fluids. Painkillers such as paracetamol can help. Talk to your doctor if the headaches are severe or do not go away.

Trouble sleeping (insomnia)

If you're finding it hard to sleep, try taking the last dose of methylphenidate more than 6 hours before bedtime.

Loss of appetite

It may help to take methylphenidate with a meal.

You may notice some weight loss during the first few months of treatment. You'll probably put this weight back on once you're used to the medicine.

If you notice that you are losing a lot of weight, speak to your doctor.

Stomach ache

Try to rest and relax. It can help to eat and drink slowly and have smaller and more frequent meals. Putting a heat pad or covered hot water bottle on your stomach may also help.

If you're in a lot of pain, or the pain does not go away, speak to your pharmacist or doctor.

Dry mouth

This usually gets better quite quickly. Taking sips of water and eating citrus fruits (like oranges or satsumas) can help.

Feeling or being sick

Stick to simple meals and do not eat rich or spicy food if you feel sick. It might help to take methylphenidate with or after a meal or snack.

If you are being sick try taking small, frequent sips of water or squash to avoid dehydration. See your doctor if you are being sick or having severe stomach pains.

If you take the combined contraceptive pill or progestogen-only pill and you're being sick, your contraception may not protect you from pregnancy. Check the pill packet for advice.

Keep taking your medicine but tell your doctor if these side effects bother you or do not go away.

Your doctor should review your medicine at least once a year to make sure there are no problems.

View the original NHS website page ↗. Refreshed 19 August 2026.

Licensed under the Open Government Licence v3.0 ↗. MyPHU is independent and is not endorsed by the NHS.

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