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Detailed medicine guidance

Who can and cannot take methadone

NHS medicines information on who can take methadone and who may not be able to take it.

About this information

This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.

Who can take methadone

Most adults aged 18 years and over, and occasionally younger people, can take methadone for heroin dependence.

Who may not be able to take methadone

Methadone may not be suitable for some people. To make sure it's safe for you, tell your doctor or prescriber before starting methadone treatment if you:

  • have ever had an allergic reaction to methadone or any other medicine
  • have a lung condition, or breathing difficulties
  • have ever abused or been dependent on alcohol, prescription medicines or illegal drugs
  • have a head injury or get bad headaches
  • have ulcerative colitis
  • have seizures or fits
  • have heart disease, heart rhythm problems (arrhythmia) or low blood pressure
  • have problems with your thyroid, adrenal glands, kidneys or liver
  • have myasthenia gravis (a rare condition that causes muscle weakness)
  • are pregnant, trying to get pregnant or breastfeeding

View the original NHS website page ↗. Refreshed 19 August 2026.

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