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Detailed medicine guidance

Taking loperamide with other medicines and herbal supplements

NHS medicines information on possible interactions with loperamide and other medicines, herbal remedies and supplements.

About this information

This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.

Cautions with other medicines

There are some medicines that can affect how loperamide works.

Tell your doctor or pharmacist if you're taking:

  • clozapine, a medicine used to treat mental health conditions
  • ritonavir, a medicine for HIV infection
  • quinidine, a medicine for abnormal heartbeats or malaria
  • itraconazole, medicines for fungal infections
  • gemfibrozil, a medicine for high cholesterol
  • desmopressin, a medicine for bedwetting or peeing too much
  • other medicines for diarrhoea, constipation, or any other stomach and bowel problems

Speak to your doctor if your diarrhoea is very severe and you take metformin for diabetes, or medicines for high blood pressure or heart failure. Your doctor may tell you to stop taking these medicines for a few days until your diarrhoea is better.

Mixing loperamide with herbal remedies and supplements

There's not enough information to say that complementary medicines and herbal remedies are safe to take with loperamide. They're not tested in the same way as pharmacy and prescription medicines. They're generally not tested for the effect they have on other medicines.

Meds New IA (H2) - Cautions with other medicines alert

Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.

View the original NHS website page ↗. Refreshed 19 August 2026.

Licensed under the Open Government Licence v3.0 ↗. MyPHU is independent and is not endorsed by the NHS.

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