This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.
Common side effects of ketoconazole
You're unlikely to have side effects with ketoconazole shampoo if you use the right amount.
With ketoconazole cream, common side effects happen in more than 1 in 100 people. They usually affect your skin where you've applied the cream.
You may have itching, a burning feeling or redness on your skin, although redness may be less obvious on brown or black skin.
If any of these happen, try using less cream. Apply it carefully, just to the area you need to treat. Rub it in gently. Try wearing loose clothing to reduce sweat.
If the itching, redness or burning feeling is no better after a few days, or if it gets worse at any time, stop using the cream and speak to a pharmacist or doctor.
Also speak to them if a side effect spreads beyond the area of skin you've treated.
View the original NHS website page ↗. Refreshed 19 August 2026.
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