This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.
Common side effects of isosorbide mononitrate or isosorbide dinitrate
There are things you can do to help cope with these common side effects of isosorbide mononitrate or isosorbide dinitrate:
Headaches
Make sure you rest and drink plenty of water. Paracetamol is safe to take with isosorbide mononitrate and isosorbide dinitrate. Do not drink alcohol, as it could make your headaches worse.
Headaches usually go away after a few days. Talk to your doctor if they do not go away or are severe.
Feeling dizzy, weak, tired or sleepy
Stop what you're doing and sit or lie down until you feel better. Do not drink alcohol, as it could make you feel worse. Do not drive, ride a bike or use tools or machinery until you feel better.
Feeling sick (nausea)
Avoid rich, greasy or spicy foods, as these could make you feel worse. Stick to small, simple snacks or meals if you're hungry. It might help to take isosorbide mononitrate or isosorbide dinitrate after meals.
Flushing of the face
Try to cut down on coffee, tea and alcohol because they can make flushing worse. It might help to keep the room cool and use a fan. You could also spray your face with cool water or sip non-alcoholic cold or iced drinks.
Talk to your doctor or pharmacist if the advice on how to cope does not help and a side effect is still bothering you or does not go away.
View the original NHS website page ↗. Refreshed 19 August 2026.
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