This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.
Common side effects of flucloxacillin
These common side effects of flucloxacillin happen in more than 1 in 100 people. There are things you can do to help cope with them:
Feeling or being sick
Stick to simple meals and try not to eat rich or spicy food.
If you're being sick, take small, frequent sips of fluids such as water or squash to avoid dehydration. Signs of dehydration include peeing less than usual or having dark, strong-smelling pee.
If you take the combined pill or the progestogen-only pill and you are being sick, your contraception may not protect you from pregnancy. Check the pill packet for advice.
Diarrhoea
Drink lots of fluids such as water or squash to avoid dehydration. Signs of dehydration include peeing less than usual or having dark, strong-smelling pee. Do not take any other medicines to treat diarrhoea without speaking to a pharmacist or doctor.
If you take the combined pill or the progestogen-only pill and you have severe, watery diarrhoea, or any diarrhoea that lasts for more than 24 hours, your contraceptive pills may not protect you from pregnancy. Check the pill packet for advice.
Bloating and indigestion
Try not to eat foods that cause farting (flatulence), like lentils, peas, beans and onions. You could also try eating smaller meals, eating and drinking more slowly, and exercising regularly.
Keep taking flucloxacillin, but talk to your doctor or pharmacist if the advice on how to cope does not help and a side effect is still bothering you or does not go away.
View the original NHS website page ↗. Refreshed 19 August 2026.
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