This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.
Cautions with other medicines
Some medicines can affect how fexofenadine works or can increase the chances of you having side effects.
Check with your pharmacist or doctor if you're taking any other medicines, including:
- leflunomide, to treat arthritis
- velpatasvir, to treat hepatitis C infection
- teriflunomide, to treat multiple sclerosis
- indigestion remedies containing aluminium or magnesium – leave about 2 hours between taking fexofenadine and taking your indigestion remedy
- apalutamide, to treat prostate cancer
- any medicine that makes you drowsy, gives you a dry mouth, or makes it difficult for you to pee – taking fexofenadine might make these side effects worse
These are not all the medicines that may cause problems if you take them with fexofenadine. For a full list, see the leaflet inside your medicine packet.
Taking fexofenadine with painkillers
You can take fexofenadine together with painkillers such as paracetamol or ibuprofen.
View the original NHS website page ↗. Refreshed 19 August 2026.
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