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Detailed medicine guidance

Side effects of domperidone

NHS medicines information on side effects of domperidone and what you can do to cope.

About this information

This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.

Common side effects

More than 1 in 100 people who take domperidone will get a dry mouth. This common side effect is usually mild and goes away by itself.

If this happens, try chewing sugar-free gum or sucking a sugar-free sweet.

Serious side effects

Serious side effects are rare.

Call a doctor or call 111 now if:

  • your muscles or eyes start moving in an unusual or uncontrolled way
  • you have problems peeing

Call 999 or go to A&E now if:

  • you have a seizure or fit
  • you have a fast or irregular heartbeat

Meds - serious side effects A&E safety messaging

Do not drive to A&E. Ask someone to drive you or call 999 and ask for an ambulance.

Bring all the medicines you take with you.

Serious allergic reaction

In rare cases, it's possible to have a serious allergic reaction (anaphylaxis) to domperidone.

Meds New IA (H4) - serious allergic reaction

Call 999 now if:

  • your lips, mouth, throat or tongue suddenly become swollen
  • you're breathing very fast or struggling to breathe (you may become very wheezy or feel like you're choking or gasping for air)
  • your throat feels tight or you're struggling to swallow
  • your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
  • you suddenly become very confused, drowsy or dizzy
  • someone faints and cannot be woken up
  • a child is limp, floppy or not responding like they normally do (their head may fall to the side, backwards or forwards, or they may find it difficult to lift their head or focus on your face)

You or the person who's unwell may also have a rash that's swollen, raised, itchy, blistered or peeling.

These can be signs of a serious allergic reaction and may need immediate treatment in hospital.

Other side effects

These are not all the side effects of domperidone. For a full list, see the leaflet inside your medicine packet.

View the original NHS website page ↗. Refreshed 19 August 2026.

Licensed under the Open Government Licence v3.0 ↗. MyPHU is independent and is not endorsed by the NHS.

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