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Detailed medicine guidance

Having medroxyprogesterone contraceptive injections with other medicines and herbal supplements

NHS medicines information on possible interactions with medroxyprogesterone contraceptive injections and other medicines, herbal remedies and supplements.

About this information

This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.

Cautions with other medicines

Other medicines will not usually affect how medroxyprogesterone contraceptive injections work.

But tell your nurse or doctor when you go for the injection if you're taking other medicines. You can also talk to a pharmacist.

Mixing medroxyprogesterone contraceptive injections with herbal remedies and supplements

Do not take St John's wort, a herbal remedy used for depression, with medroxyprogesterone contraceptive injections. It can affect the way medroxyprogesterone works.

There's not enough information to say that other complementary medicines, herbal remedies and supplements are safe to take with medroxyprogesterone contraceptive injections. They're not tested in the same way as pharmacy and prescription medicines. They're generally not tested for the effect they have on other medicines.

Meds New IA (H2) - Cautions with other medicines alert

Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.

View the original NHS website page ↗. Refreshed 19 August 2026.

Licensed under the Open Government Licence v3.0 ↗. MyPHU is independent and is not endorsed by the NHS.

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