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Detailed medicine guidance

Taking chlorphenamine with other medicines and herbal supplements

NHS medicines information on possible interactions with chlorphenamine and other medicines, herbal remedies and supplements.

About this information

This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.

Cautions with other medicines

Some medicines and chlorphenamine can affect each other and increase the chances of you having side effects.

Check with your pharmacist or doctor if you're taking any other medicines, including:

  • a type of antidepressant called a monoamine oxidase inhibitor, such as phenelzine
  • phenytoin (an anti-epilepsy medicine)
  • any medicines for anxiety or to help you sleep
  • any medicine that makes you drowsy, gives you a dry mouth, or makes it difficult for you to pee – taking chlorphenamine might make these side effects worse

These are not all the medicines that may cause problems if you take them with chlorphenamine. For a full list, see the leaflet inside your medicine packet.

Taking chlorphenamine with painkillers

It's safe to take chlorphenamine with painkillers like paracetamol or ibuprofen that you buy from a pharmacy or shop.

But if you take chlorphenamine with painkillers that contain codeine (such as co-codamol) or other prescription painkillers, you're more likely to have side effects.

View the original NHS website page ↗. Refreshed 19 August 2026.

Licensed under the Open Government Licence v3.0 ↗. MyPHU is independent and is not endorsed by the NHS.

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