Taking amitriptyline for pain and migraine with other medicines and herbal supplements

Many medicines and amitriptyline can affect each other and increase the chances of side effects.

Always check with your doctor or a pharmacist before starting any new medicine while you're taking amitriptyline.

Taking opioid-based medicines, like codeine, morphine or oxycodone, together with amitriptyline can increase your risk of becoming very drowsy and having breathing problems.

Tell your doctor if you've ever taken any medicines for depression. Some antidepressants can affect the way amitriptyline works and can cause very high blood pressure. This can happen even after you stop taking them.

Do not take St John's wort, a herbal remedy often taken for depression, while you're taking amitriptyline. It will increase your risk of side effects.

There's not enough information to say that other complementary medicines and herbal remedies are safe to take with amitriptyline. They're not tested in the same way as pharmacy and prescription medicines. They're generally not tested for the effect they have on other medicines.

Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.