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Medicine guide

Zopiclone

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This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.

Zopiclone

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Zopiclone is used for a short time if you have problems falling asleep and staying asleep. It's a type of medicine called a hypnotic.

Zopiclone comes as tablets you take once a day, just before you go to bed. Follow the instructions that come with your medicine.

Side effects of zopiclone include a dry mouth, and feeling tired or dazed the next day. More serious side effects are rare.

Zopiclone is suitable for most adults, but always check before using it because it's not suitable for everyone.

Taking zopiclone with other medicines, such as medicines for anxiety or opioid painkillers, can cause problems. Always check before taking it.

What zopiclone is for

Zopiclone is used as a short-term treatment for sleeping problems (insomnia).

A doctor may prescribe zopiclone if you have problems with falling asleep, waking up during the night or waking up too early, and it's affecting your everyday life.

It's a type of sleeping pill that's sometimes known as a Z-drug. These are a kind of medicine called a hypnotic, which affect a calming chemical in your brain.

How to take zopiclone

Zopiclone comes as tablets you swallow once a day, before you go to bed. It takes around 30 to 60 minutes to start working.

Swallow the tablets whole with a drink of water.

Treatment with zopiclone usually lasts from a few days to a few weeks. It's usually not prescribed for more than 4 weeks because your body can become used to it and it stops working as well (known as tolerance).

Always check the packet or leaflet that comes with your medicine. Ask a pharmacist or doctor for advice if you're not sure how to take it or have any problems taking it.

If you miss a dose of zopiclone

If you forget to take zopiclone, skip the missed dose and take your next dose before bed the next day as usual.

Do not take 2 doses to make up for a missed dose, and do not take more than 1 dose in the same night.

If you take too much zopiclone

Taking an extra dose of zopiclone can be dangerous.

Call NHS 111 if:

  • you have taken more than your prescribed dose of zopiclone

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If you're told to go to A&E, do not drive. Ask someone to drive you or call 999 and ask for an ambulance.

Bring the zopiclone packet or leaflet inside it, any remaining medicine, and any other medicines you take.

How to stop taking zopiclone

Do not stop taking zopiclone suddenly because this can cause withdrawal symptoms such as feeling agitated or anxious.

Your doctor will gradually reduce your dose so that you can stop taking it safely. Always follow your doctor's advice.

It's possible to become addicted to zopiclone. Your doctor will only prescribe it for a short time and will prescribe the lowest dose you need to help your sleeping problems.

Talk to your doctor if you're worried about addiction or stopping taking zopiclone.

Side effects of zopiclone

Like all medicines, zopiclone can cause side effects, although not everyone gets them.

Common side effects

Common side effects of zopiclone include:

  • dry mouth
  • a bitter or metallic taste in your mouth
  • feeling tired, sleepy, dazed or less alert the next day

Do not drive, ride a bike or use machinery for 12 hours after taking zopiclone. If you feel sleepy, dazed or less alert, wait until you no longer have these symptoms.

Speak to a pharmacist or doctor if:

  • you have any side effects that bother you or do not go away

They may be able to give you advice about how to reduce any side effects. Keep taking your medicine unless you're advised to stop.

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Serious side effects

Zopiclone can sometimes cause more serious side effects, although most of them are rare.

Possible serious side effects of zopiclone include:

  • difficulty breathing
  • sleepwalking, or doing things while not fully awake, like eating, talking on the phone or driving
  • an allergic reaction (anaphylaxis) – causing symptoms such as a swollen throat or tongue, a raised, itchy rash and difficulty breathing
  • mental health problems – such as hearing or seeing things that are not there (hallucinations), believing things that are not true (delusions), feeling low or depressed, or having thoughts of suicide or harming yourself

Call NHS 111 if:

  • you're taking zopiclone and think you might be having serious side effects
  • you're having thoughts about harming yourself

Who can and cannot take zopiclone

Most adults can take zopiclone.

However, it's not suitable for everyone. For example, it may not be suitable if:

  • you've had a serious side effect or allergic reaction to zopiclone or a similar medicine before, such as other sleeping pills or sedatives
  • you have muscle weakness or a condition that causes it, such as myasthenia gravis
  • you have sleep apnoea or breathing problems
  • you have liver problems
  • you've been addicted to alcohol, drugs or prescription medicine before, especially opioids

Before taking zopiclone, tell your doctor if you have any other medical conditions.

Breastfeeding and zopiclone

Tell your doctor if you're breastfeeding.

Zopiclone can be used for a short time while breastfeeding, but check with your doctor because the medicine can pass into your breast milk in small amounts.

It's rare for breastfed babies to get any side effects of medicines you're using, but speak to a healthcare professional or call NHS 111 if you have any concerns about your baby.

Do not sleep in the same bed (co-sleep) with your baby if you've taken zopiclone or any other medicine that makes you sleepy or drowsy, as it can increase the risk of sudden infant death syndrome (SIDS).

Pregnancy and zopiclone

Tell your doctor if you're pregnant or you get pregnant while taking zopiclone.

Zopiclone is not usually used during pregnancy but may sometimes be prescribed for a short time if your sleeping problems are severe and other treatments have not worked.

Taking zopiclone with other medicines, food and drink

There are some medicines, remedies and supplements that may not mix well with zopiclone.

These include some:

Before taking zopiclone, tell your doctor if you're taking any other medicines, herbal remedies, vitamins or supplements.

Food, drink and alcohol with zopiclone

Do not drink alcohol while taking zopiclone. Alcohol can increase the effects of the medicine, which can cause breathing problems and make it very difficult to wake up.

Apart from alcohol, you can eat and drink as usual while taking zopiclone.

Content supplied by the NHS website

Content supplied by the NHS website, refreshed 19 August 2026. View the original NHS article ↗

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